Sigma-1 receptor antagonist 4 - Search Results

About 4 results found for searched term "Sigma-1 receptor antagonist 4" (0.133 seconds)

Cat.No.	Name	Target
M42693	Sigma-1 receptor antagonist 4	Sigma Receptor
	Sigma-1 receptor antagonist 4 is a potent σ1R antagonist that significantly enhances the analgesic effect of morphine and rescues morphine-induced analgesic tolerance.
M28096	S1RA hydrochloride	Sigma Receptor
	E-52862 hydrochloride
	S1RA (E-52862) hydrochloride is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization.
M28534	NE-100 hydrochloride	Sigma Receptor
	NE-100 (hydrochloride) is a potent and selective sigma-1 receptor antagonist with an IC50 of 4.16 nM. NE-100 (hydrochloride) exerts antipsychotic activity in vivo. NE-100 (hydrochloride) also suppresses ER stress-induced hippocampal cell death.
M42694	KSK68	Sigma Receptor
	KSK68 is a high-affinity dual sigma-1 and histamine H3 receptor antagonist, with Kis of 7.7, 3.6, 22.4 nM for H3 receptor, sigma-1, sigma-2 receptor respectively.